α-Glycerophosphate Oxidase of Flight Muscle Mitochondria
نویسندگان
چکیده
منابع مشابه
4Glycerophosphate Bxidase of Flight Muscle Mitochondria
The oxidation of ar-glycerophosphate (glycerol-3-P)’ by tissue preparations was first described by Meyerhof (1). Subsequent studies showed that mammalian tissues contained two types of glycerol-3-P dehydrogenases; one, characterized as a soluble, diphosphopyridine nucleotide-linked enzyme (2, 3) ; the other, as a structurally bound dehydrogenase, not requiring pyridine nucleotide but reacting v...
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UNLABELLED The formation of H2 O2 by the FAD-dependent L-α-glycerophosphate oxidase (GlpO) is important for the pathogenesis of Streptococcus pneumoniae and Mycoplasma pneumoniae. The structurally known GlpO from Streptococcus sp. (SspGlpO) is similar to the pneumococcal protein (SpGlpO) and provides a guide for drug design against that target. However, M. pneumoniae GlpO (MpGlpO), having < 20%...
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Blowfly flight muscle mitochondria differ markedly from mammalian mitochondria in their interaction with Ca2+. State 4 respiration of blowfly mitochondria is not stimulated by Ca2+, nor does Ca*+ induce a reversible shift in the oxidation-reduction state of cytochrome b. Nevertheless, CaZf is accumulated by respiring blowfly mitochondria, but with a low efficiency; the Ca2+: N accumulation rati...
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Different tissues, especially muscles, from insects belonging to various groups were extracted and studied for their lactic dehydrogenase (LDH) and alpha-glycerophosphate dehydrogenase (GDH I) activities from the comparative point of view. In all cases assays of flight muscle extracts showed extremely low values of LDH activity whereas the GDH activities were surprisingly high. The activities i...
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"Null" mutations previously isolated at the alphaGpdh-1 locus of Drosophila melanogaster, because of disruption of the energy-producing alpha-glycerophosphate cycle, severely restrict the flight ability and relative viability of affected individuals. Two "null" alleles, alphaGpdh-1(BO-1-4), and alphaGpdh-1(BO-1-5,) when made hemizygous with a deficiency of the alphaGpdh-1 locus, Df(2L)GdhA, wer...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1958
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64696-4